|
KMID : 0604520160420010057
|
|
Journal of the Society of Cosmetic Scientists of Korea
2016 Volume.42 No. 1 p.57 ~ p.64
|
|
|
Inhibitory Effects of Dunaliella salina Extracts on Thermally-Induced Skin Aging
|
|
Joo Ji-Hye
Seok Ji-Hyun
Hong In-Kee
Kim Nam-Kyoung
Choi Eun-Mi
|
|
|
Abstract
|
|
|
|
Just like UV radiation, heat increases collagen degradation and accumulation of abnormal elastin fiber and this is termed thermal skin aging. Dunaliella salina (DS), a green alga, is known for its beta-carotene accumulation, having various applications in the health and nutritional products. However, the effects of DS on heat-induced skin aging remain unexplored. In this study, we performed anti-thermal aging tests of the ethanol extract of DS (DSE). We measured the cellular levels of type I procollagen and MMP-1 using ELISA in human dermal fibroblast cells after heat shock. DSE reduced the expression of MMP-1 protein and increased the expression of type I procollagen. In addition, DSE upregulated the mRNA expression of HSP47 reduced by heat shock, which is involved in collagen synthesis. Also, DSE reduced the expression of inflammation mediator (TGF-β, IL-12, etc). We demonstrate that DSE regulates the heat-induced solar elastosis through the regulation of tropoelastin and fibrillin-1, two major proteins of elastic fibers, and MMP-12 expression. These results suggest that DSE may be effective for preventing thermally induced skin aging.
|
|
|
KEYWORD
|
|
|
Dunaliella salina, thermal aging, heat shock, type I procollagen, solar elastosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|